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This course builds on the on the medical microbiology and introductory immunology study in second year and is designed to consolidate the student鈥檚 knowledge of the essential mechanisms and pathways of a normally functioning human immune system. The course then aims to provide students with an advanced understanding of immunological diseases that are derived from inherited and acquired sources of which many are diagnosed by the propensity for the host to develop infections. Students also undertake instruction in a broad spectrum of immunological diseases including organ specific and systemic autoimmune diseases, tissue allograft rejection and immunodeficiency.
Detailed analysis of specific immune disease syndromes, together with discussion of relevant diagnostic and therapeutic options will enable the student to integrate and advance their investigative skills that can be applied to a range of associated pathology orientated clinical disciplines such as histopathology, haematology, biochemistry and molecular pathology. This study will enhance the student鈥檚 capacity to make critical and informed judgements in a professional clinical sciences setting.

As part of the USQ accreditation agreement with the Australian Institute of Medical and Clinical Scientists (AIMS), students are required to attempt and submit all assessment items in this course. Students are also required to obtain at least 50% of the marks allocated to the practical/laboratory skills assessment in this course.

This course builds on the foundation theoretical knowledge and practical skill set provided in previous courses in medical microbiology and immunology and provides students with an advanced level of study of the principal mechanisms and pathways that underpin a functional immune system; the pathogenesis of inherited and acquired immunological dysfunctions and the associated host susceptibilities to infectious diseases. This course will consolidate a student's understanding of clinical immunology and then present advanced studies in immunopathology from both innate and acquired disease perspectives that has a focus on understanding dysfunctional immune regulation, aberrant hypersensitivity reactions, immunodeficiency, autoimmunity and allograft rejection. The student's comprehension of specific immunological pathologies will be further supplemented with applied case studies. Students will also gain an advanced understanding of the relationship between immune dysfunction and increased susceptibility to infectious diseases. Analysis of complex case studies in dysfunctional immunological syndromes, including emerging immunodeficiency states and autoimmune diseases will continue to provide opportunities for students to develop their investigative and reporting skills. This course will provide students an opportunity to further advance their practical skills in a setting that will also encourage critical thinking during the generation, analysis, interpretation and reporting of complex microbiological data.

This course contains a mandatory residential school for both external and on-campus students.

On completion of this course students should be able to:

1. Detail the fundamental nature of a normally functioning immune system including differentiating the ontogeny and effector functions of immune cells and the role of MHC I and MHC II in allograft rejection and CD4 and CD8 cell functionality;
2. Interpret the role of T cells in immunological functionality including the nature of cytokines mediation on effector functions such immune regulation and immune tolerance;
3. Describe the nature of normal and dysfunctional effector functions of innate, adaptive and acquired immune modalities such as hypersensitivity, inflammation, transplantation, vaccinology, immunotherapy, as well as specific immunopathology syndromes of autoimmunity, immunodeficiency, immune tolerance;
4. Describe the pathogenesis and diagnosis of specific autoimmune diseases including Rheumatic Heart Disease, Systemic Lupus Erythematosus, Sjogren Syndrome, Systemic sclerosis and other immune syndromes and perform analysis of clinical case studies associated with specific autoimmune syndromes;
5. Explain the correlation between immunological disease and the host susceptibility to specific or recurrent infections;
6. Discuss the practice of clinical microbiology in terms epidemiology, antimicrobial therapeutics and infection control guidelines;
7. Perform complex laboratory experiments safely, including conventional and molecular microbiological and immunological investigative methods, data generation, analysis, interpretation and reporting;
8. Critically review and interpret relevant literature from research databases in order to analyse laboratory and clinical case studies;
9. Display safe infection management and infection control practices relevant to both university residential schools and professional pathology laboratory settings and comply with ethical and privacy standards mandated for the professional healthcare and academic settings.